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Methylene Blue

Updated: Oct 24, 2023

Miracle Molecule To Increase Energy, Reverse Aging & Treat Illness

Methylene Blue
Methylene Blue

Imagine a drug – more than a century old – with such complex and elegant pharmacokinetics to gently but effectively treat an amazingly wide diversity of medical illness including but not limited to:

  • Dementia

  • Mood disorders

  • Parkinson’s disease

  • Traumatic brain injury

  • Carbon monoxide poisoning

  • Methemoglobinemia

  • Refractory hypotension

  • Cyanide poisoning

  • Urinary infections

  • Liver infections

  • Septic shock

  • HIV infection

  • Malaria

  • Priapism

  • Cancer

What medication could possibly do all that? Is it safe? Affordable? Available? If it is, why haven't you heard of it? Something Old... A little history on methylene blue. Methylene blue – a thiazine dye initially used as an antiseptic - was discovered in the late 1800s by a German scientist, Heinrich Caro. It was the very first fully synthesized medication approved to treat illness in humans long before there was an official ‘FDA’ approving medications for anything. Methylene blue was discovered and used as a stain (guess the color) in textiles and also to treat malaria – a therapy pioneered by Paul Guttmann and Paul Ehrlich in 1891. In addition to being an antimalarial agent, methylene blue was also found to exhibit antioxidant, antidepressant, nootropic, and cardioprotective properties. At the time, methylene blue wasn’t particularly favorable among the regular folks – not for lack of effectiveness, but because like King Midas, everything it touched turned to gold. Or to blue, rather. And when I say blue, I mean blue blue. Green urine, blue sclera - this weirded out enough of the 19th century humans to temporarily diminish its popularity. Fun fact: Methylene blue is a derivative of phenothiazine, a dark green powder that becomes a blue solution when mixed with water. If you find yourself tempted to sip the liquid version of this mitochondrial mystery, do so at your own risk – or at least with a straw. I remember methylene blue in a PTSD flashback from chemistry lab back in college. We used something called 'Geimsa stain' - a methylene blue containing solution to stain cells on microscopy slides. Seriously, you hoped like hell you didn’t get any of this stuff on your shirt. Or worse – your skin. That blue blemish was not coming out of anything, anytime in your lifetime. I think you can purchase USP grade methylene blue in a drinkable tincture over the counter, but you’d want to do lots of praying it didn’t touch any of your teeth if you decided to take a sip. Unless it was Halloween - then it would be awesome. Something New... Soo, what does it do, this methylene blue? So so much! Shall we start with physiologically? Or clinically? I’m better at the latter on account of the fact that I’ve tried to block out much of the cell microbiology I learned under duress as a med student. Methylene blue has countless miraculous effects on our cells (decreases production of reactive oxygen species, protects neurons from toxicity, kills pathogens on contact, absorbs energy directly from light, damages cancer cells, protects healthy cells, accepts electrons directly as an antioxidant, enhances thyroid hormone production, protects liver from harmful effects of alcohol, increases dopamine, supports optimal estrogen metabolism, inhibits monoamine oxidase, etc, etc, etc.) but, it is probably most notable for being a direct electron donor to the mitochondrial electron transport chain. This is the primary pathway responsible for energy production in EVERY SINGLE CELL in the body. It doesn’t matter what’s wrong with that critical pathway, methylene blue fixes it. As demonstrated by an image lifted from the GOAT of artistic medical education himself, the good Dr. Sayeed Mobeen, methylene blue accomplishes something remarkable: it feeds your mitochondria energy and oxygen.


What Is A Mitochondria? OK – Skip ahead if your brain is melting with the 5 syllable words. For the rest of you, I promise to try to make this as painless as humanly possible:

  • Your body is made up of a whole bunch of different kinds of cells smashed together in a convenient, probably divinely designed system - each of those systems doing something completely different from one another.

  • Individually, your cells are like worker bees taking care of operations on a day-to-day basis. They do all the things needed to keep you functioning – the cooking, the cleaning, the candlestick making – all the mindless stuff to make sure you show up to work every day and stay out of jail.

INSIDE your cells, there are many amazing things:

  • Mitochondria are one of those amazing things.

  • Mitochondria are “organelles” - special little machines that live inside each and every one of your cells.

  • Mitochondria are super important because they make all the energy you need – it's called ATP (adenosine triphosphate).

  • Mitochondria also tell your cells how to use oxygen – or how to breathe. Breathing, as you know from previous life experience, is very important.

Methylene blue helps your mitochondria work better. Better mitochondria = more energy for your cells = a supercharged system ready to take on the world. Something Borrowed... "It's not easy being a mom. If it were easy, fathers would do it." - Betty White Whether you like your parents or not, your genetic makeup is 100% theirs: 50% from mom and 50% from dad. Whether you like your brothers and sisters or not, you share a full 50% of your DNA with each and every one of them. The rest of your parental hand me downs are just plain unequally distributed, let's just be honest. Genetic transmission takes a detour here. Your height, hair color, sense of humor, athletic prowess, and likelihood of being a Rhodes Scholar, are aligned with your cellular DNA. Some of those genes are turned on, some of them are turned off, but all are sourced from the same pool of 50% mom, 50% dad – minus a few exceptions. Aside from mature red blood cells, your mitochondria contain roughly 150,000 genes that are inherited by one parent and one parent only –

Your mother’s.

Thank your mother!

Laughing.... Totally kidding – you love your mother:)

Mitochondria are critical to our survival - but they don’t share our same genome - they have their own DNA. As stated above, mitochondria are critical to healthy functioning of each cell in the body. There are many theories as to how they got there, but these powerhouses carry their own unique set of genes which were passed down generation to generation from your maternal DNA only.

Thank your mother. Something Blue... This should now go without saying, but methylene blue is first and foremost – BLUE. Smurf blue. I would put any money on the blue of Smurfs being derived 100% from methylene blue. Seriously. Where else? Although initially developed as a dye, methylene blue has shown itself to be a miracle molecule – an antimalarial drug that treats everything from UTIs to cancer. Amazing.

Methylene Blue
Methylene Blue

Methylene Blue

Take Aways About Methylene Blue

- Improves cellular efficiency - Increases cell energy production - Increases nitric oxide production - Improves cell respiration/oxygenation - Increases cognitive function - Reduces pain and inflammation - Protects against infections - Improves/stabilizes mood - Decreases symptoms of PTSD and bipolar disorder - Protects against neurodegenerative disease - Reduces risk and symptoms of Parkinson’s and Alzheimer’s disease - Memory improvement - Protects against and fights cancer - Powerful anti-aging agent - Treats methemoglobinemia, carbon monoxide, and cyanide toxicity - Antiviral effects against SARS-CoV-2... Most importantly, it turns urine SMURF BLUE. The best party trick EVER. For More Information: Methylene Blue: The Long and Winding Road from Stain to Brain: Part 1 Methylene Blue: The Long and Winding Road from Stain to Brain: Part 1 Treatment of cancer with antipsychotic medications: Pushing the boundaries of schizophrenia and cancer Methylene Blue in the Treatment of Neuropsychiatric Disorders Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots Protection against neurodegeneration with low-dose methylene blue and near-infrared light Cellular and Molecular Actions of Methylene Blue in the Nervous System Methylene blue inhibits replication of SARS-CoV-2 in vitro From Mitochondrial Function to Neuroprotection – An Emerging Role for Methylene Blue Methylene blue photodynamic therapy induces selective and massive cell death in human breast cancer cells COVID-19 Treatment Using Methylene Blue and Photodynamic Therapy

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